Cart
sales@molnova.com
O-Desmethyl gefitinib
CAS No. 847949-49-9
O-Desmethyl gefitinib ( —— )
Catalog No. M22714 CAS No. 847949-49-9
O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 102 | In Stock |
|
| 10MG | 161 | In Stock |
|
| 25MG | 324 | In Stock |
|
| 50MG | 518 | In Stock |
|
| 100MG | 743 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameO-Desmethyl gefitinib
-
NoteResearch use only, not for human use.
-
Brief DescriptionO-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib.
-
DescriptionO-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 activity.
-
Synonyms——
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorEGFR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number847949-49-9
-
Formula Weight432.88
-
Molecular FormulaC21H22ClFN4O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kobayashi H, et al. Effects of polymorphisms in CYP2D6 and ABC transporters and side effects induced by gefitinib on the pharmacokinetics of the gefitinib metabolite, O-desmethyl gefitinib. Med Oncol. 2016 Jun;33(6):57.
molnova catalog
related products
-
ARRY380
ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM.
-
ICA-105574
ICA-105574 is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action potential. It also modulates activation kinetics of the channel.
-
AG18
AG-18(RG-50810; Tyrphostin A23) inhibits EGFR with IC50 of 35 μM.
